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Results for "

TPH inhibitor

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

1

Peptides

2

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14454
    TPh A
    1 Publications Verification

    Triphenyl Compound A

    		 Others Cancer
    TPh A (Triphenyl Compound A) is a potent inhibitor of the nuclear protein pirin and binds specifically to pirin with a Ki of 0.6 uM. TPh A disrupts the formation of the bcl3–pirin complex. TPh A can be used as a novel small molecule tool to regulate pirin in cells .
    TPh A
  • HY-W019599
    4-Chloro-L-phenylalanine

    L-PCPA

    		 5-HT Receptor Tryptophan Hydroxylase Neurological Disease
    4-Chloro-L-phenylalanine (L-PCPA) is a 5-HT biosynthesis inhibitor. 4-Chloro-L-phenylalanine is also a nonspecific antagonist of both isoforms of tryptophan hydroxylase (TPH1 and TPH2) .
    4-Chloro-L-phenylalanine
  • HY-120083
    Rodatristat

    KAR5417

    		 5-HT Receptor Tryptophan Hydroxylase Cardiovascular Disease
    Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice .
    Rodatristat
  • HY-19572
    ACT-678689

    ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM .
    ACT-678689
  • HY-156093
    TPH1-IN-1

    		Tryptophan Hydroxylase Metabolic Disease
    TPH1-IN-1 (compound 40) is a xanthine derivative and an inhibitor of tryptophan hydroxylase TPH1 (IC50: 110.1 nM). TPH1-IN-1 has good in vitro activity and liver microsome stability, and effectively inhibits adipocyte differentiation of T3-L1 cells .
    TPH1-IN-1
  • HY-13041
    LX-1031
    1 Publications Verification

    		 Tryptophan Hydroxylase Neurological Disease
    LX-1031 is a potent, orally available tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) synthesis peripherally.
    LX-1031
  • HY-157014
    TPT-004

    		Tryptophan Hydroxylase Cancer
    TPT-004 is a TPH inhibitor. TPT-004 has superior pharmacokinetic and pharmacodynamic properties. TPT-004 also has good efficacy in preclinical models of peripheral serotonin attenuation and colorectal tumor growth .
    TPT-004
  • HY-101124
    Rodatristat ethyl

    KAR5585

    		 Tryptophan Hydroxylase 5-HT Receptor Cardiovascular Disease
    Rodatristat ethyl (KAR5585) is a first-in-class oral tryptophan hydroxylase 1 (TPH1) Inhibitor with nanomolar in vitro potency. Rodatristat ethyl reduces the level of 5-HT and significantly reduces pulmonary arterial hypertension (PAH) .
    Rodatristat ethyl
  • HY-23460
    p-Ethynylphenylalanine
    1 Publications Verification

    4-Ethynyl-L-phenylalanine

    		 Tryptophan Hydroxylase Neurological Disease
    p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM . p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    p-Ethynylphenylalanine
  • HY-23460A
    p-Ethynylphenylalanine hydrochloride
    1 Publications Verification

    4-Ethynyl-L-phenylalanine hydrochloride

    		 Tryptophan Hydroxylase Neurological Disease
    p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM . p-Ethynylphenylalanine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    p-Ethynylphenylalanine hydrochloride

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